{"id":9490,"date":"2026-07-08T19:48:04","date_gmt":"2026-07-08T19:48:04","guid":{"rendered":"https:\/\/godshand.link\/ground_post\/who-optimal-antiretroviral-dosing-guidance-recommendations-for-dosing-medicines-for-hiv-prevention-and-treatment-in-paediatric-populations\/"},"modified":"2026-07-08T19:48:04","modified_gmt":"2026-07-08T19:48:04","slug":"who-optimal-antiretroviral-dosing-guidance-recommendations-for-dosing-medicines-for-hiv-prevention-and-treatment-in-paediatric-populations","status":"publish","type":"ground_post","link":"https:\/\/godshand.link\/en_gb\/ground_post\/who-optimal-antiretroviral-dosing-guidance-recommendations-for-dosing-medicines-for-hiv-prevention-and-treatment-in-paediatric-populations\/","title":{"rendered":"WHO optimal antiretroviral dosing guidance: recommendations for dosing medicines for HIV prevention and treatment in paediatric populations"},"content":{"rendered":"<p><br \/>\n<\/p>\n<section class=\"dynamic-content__section dynamic-content__container\">\n<div class=\"dynamic-content__section-container\">\n<div class=\"dynamic-content__figure-container\">\n<figure class=\"dynamic-content__figure\">\n      <img decoding=\"async\" src=\"https:\/\/iris.who.int\/server\/api\/core\/bitstreams\/69a46e29-09db-4bff-8afc-bcb88ea670ab\/content\" alt=\"WHO optimal antiretroviral dosing guidance: recommendations for dosing medicines for HIV prevention and treatment in paediatric populations\"><br \/>\n     <\/figure>\n<div class=\"button button-blue-background\"><a target=\"_blank\" href=\"https:\/\/iris.who.int\/server\/api\/core\/bitstreams\/4c00671d-bd97-4eaf-9868-4319d481b094\/content\" onclick=\"sendGaEvent('Download','https:\/\/iris.who.int\/server\/api\/core\/bitstreams\/4c00671d-bd97-4eaf-9868-4319d481b094\/content')\">Download <span>(2.5 MB)<\/span><\/a><\/div><\/div>\n<div class=\"dynamic-content__description-container\">\n<div class=\"row\">\n<div class=\"col-md-8\">\n<div class=\"dynamic-content__description\">\n<h3>Overview <\/h3>\n<p>This guidance presents updated recommendations on antiretroviral drug dosing for neonates, infants and children, drawing on recent pharmacokinetic evidence, clinical studies and expert consensus to support HIV prevention and treatment in paediatric populations.\n<\/p>\n<p>The document outlines harmonized weight-band dosing approaches intended to simplify prescribing, dispensing and programme implementation while maintaining appropriate drug exposure across age groups. It describes key updates to neonatal and paediatric dosing, including revised regimens for commonly used medicines such as dolutegravir and abacavir\/lamivudine, and provides detailed dosing tables for a range of formulations. <\/p>\n<p>Additional sections address considerations for preterm infants, differences between prophylaxis and treatment, and dose adjustments in the context of tuberculosis co-treatment. Programme and regulatory aspects, as well as evidence gaps and priorities for future formulation development, are also highlighted to support clinicians, programme managers and policy-makers in delivering effective paediatric HIV care.<\/p>\n<div id=\"dynamic-content__accordion\" class=\"dynamic-content__accordion\">\n<h3>Related<\/h3>\n<p><a target=\"_blank\" href=\"https:\/\/www.who.int\/groups\/antiretroviral-drug-optimization\">Antiretroviral Drug Optimization<\/a><\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.who.int\/teams\/global-hiv-hepatitis-and-stis-programmes\/hiv\/treatment\/treatment-and-care-in-children-and-adolescents\">Treatment and care in children and adolescents<\/a><\/p>\n<p><a target=\"_blank\" href=\"https:\/\/www.who.int\/teams\/global-hiv-hepatitis-and-stis-programmes\/hiv\/overview\">Technical information on HIV<\/a><\/p>\n<\/p><\/div><\/div><\/div>\n<div class=\"col-md-4\">\n<div class=\"dynamic-content__details\">\n<div class=\"detail who-team\">\n<div class=\"label\">WHO Team<\/div>\n<div class=\"value\">\n                 <span><br \/>\nHIV, TB, Hepatitis and STIs (HTH)                 <\/span>\n         <\/div><\/div>\n<div class=\"detail\">\n<div class=\"label\">Editors<\/div>\n<div class=\"value\">World Health Organization<\/div><\/div>\n<div class=\"detail\">\n<div class=\"label\">Number of pages<\/div>\n<div class=\"value\">27<\/div><\/div>\n<div class=\"detail\">\n<div class=\"label\">Reference numbers<\/div>\n<div class=\"value\">\n<div><strong class=\"label-sm\">WHO Reference Number: <\/strong><span>10.2471\/B09711<\/span><\/div><\/div><\/div>\n<div class=\"detail\">\n<div class=\"label\">Copyright<\/div>\n<p>                <a target=\"_blank\" class=\"creativecommons-icons-wrappers\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/igo\/deed.en\" rel=\"license\" title=\"Click here to see the details of CC BY-NC-SA 3.0 IGO\"><br \/>\n                        <img decoding=\"async\" src=\"https:\/\/www.who.int\/ResourcePackages\/WHO\/assets\/icons\/cc-icons\/cc.svg\"><br \/>\n                        <img decoding=\"async\" src=\"https:\/\/www.who.int\/ResourcePackages\/WHO\/assets\/icons\/cc-icons\/by.svg\"><br \/>\n                        <img decoding=\"async\" src=\"https:\/\/www.who.int\/ResourcePackages\/WHO\/assets\/icons\/cc-icons\/nc.svg\"><br \/>\n                        <img decoding=\"async\" src=\"https:\/\/www.who.int\/ResourcePackages\/WHO\/assets\/icons\/cc-icons\/sa.svg\"><br \/>\n                <\/a>\n        <\/div><\/div><\/div><\/div><\/div><\/div>\n<\/section>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.who.int\/publications\/i\/item\/10-2471-B09711?rand=6398\" target=\"_blank\">Source link <\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Download (2.5 MB) Overview This guidance presents updated recommendations on antiretroviral drug dosing for neonates, infants and children, drawing on recent pharmacokinetic evidence, clinical studies and expert consensus to support HIV prevention and treatment in paediatric populations. The document outlines harmonized weight-band dosing approaches intended to simplify prescribing, dispensing and programme implementation while maintaining appropriate drug exposure across age groups.&hellip;<\/p>","protected":false},"author":99035,"featured_media":9491,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"tags":[2914,2915,1033,494,1847,2913,2697,2587,912,493,811],"ground_category":[315,316],"class_list":["post-9490","ground_post","type-ground_post","status-publish","format-standard","has-post-thumbnail","hentry","tag-antiretroviral","tag-dosing","tag-guidance","tag-hiv","tag-medicines","tag-optimal","tag-paediatric","tag-populations","tag-prevention","tag-recommendations","tag-treatment","ground_category-2-grounds-tribulation","ground_category-2-1-time-disease"],"fifu_image_url":"https:\/\/iris.who.int\/server\/api\/core\/bitstreams\/69a46e29-09db-4bff-8afc-bcb88ea670ab\/content","_links":{"self":[{"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/ground_post\/9490","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/ground_post"}],"about":[{"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/types\/ground_post"}],"author":[{"embeddable":true,"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/users\/99035"}],"replies":[{"embeddable":true,"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/comments?post=9490"}],"version-history":[{"count":0,"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/ground_post\/9490\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/media\/9491"}],"wp:attachment":[{"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/media?parent=9490"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/tags?post=9490"},{"taxonomy":"ground_category","embeddable":true,"href":"https:\/\/godshand.link\/en_gb\/wp-json\/wp\/v2\/ground_category?post=9490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}